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Compound Profile
Quinone methide triterpenoid linked to HSP90 inhibition and NF κB suppression.
Evidence level
Limited evidence
Typical onset
Varies by prep
Safety rating
Use extra caution: Generally well tolerated caution
Best for
Anxiety, Inflammation
Avoid / review if
High Caution Compound With Narrow Therapeutic Window In Preclinical Literature. Do Not Infer Supplement Safety, Avoid Pregnancy, Liver/Kidney Disease
Review before use if any apply: High Caution Compound With Narrow Therapeutic Window In Preclinical Literature. Do Not Infer Supplement Safety, Avoid Pregnancy, Liver/Kidney Disease.
Celastrol has a limited evidence evidence rating.
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
Compare side-by-side tradeoffs or verify active marker guidelines.
Independent database mapping. Sourcing availability is evaluated separately from safety and clinical efficacy scores.
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