Evidence Database
Supplement Evidence Lookup
Search 565 compounds by name or filter by clinical evidence tier — from strong human trials to mechanism-only data. The list is generated from the current research library, so it stays aligned as the workbook changes.
1(1 compound)
2(1 compound)
5(1 compound)
A(49 compounds)
AcarboseLimitedacemannanLimitedacetateStrongacetyl-11-keto-beta-boswellic acidLimitedacetyl-beta-boswellic acidLimitedAcetyl-L-CarnitineMechanismacetylshikoninLimitedActeinModerateacteosideLimitedAdenosineLimitedaescinLimitedAgaricus blazeiLimitedAged Garlic ExtractModerateAgmatine sulfateMechanismajoeneLimitedalbiflorinLimitedAlkylamidesModerateAllicinModeratealpha-asaroneLimitedAlpha-GPCMechanismAlpha-Lipoic AcidStrongalpha-mangostinLimitedAmerican Ginseng ExtractMechanismAnandamideLimitedAndrographisModerateAndrographolideMechanismanetholeLimitedangelicinLimitedApigeninMechanismArabinoxylanMechanismarginineMechanismarjunolic acidLimitedartemisininLimitedartemisinin bStrongartesunateStrongArtichoke ExtractMechanismAshitaba ExtractStrongAshwagandha KSM-66 extractMechanismAshwagandha Root ExtractMechanismasiatic acidModerateasiaticosideLimitedaspalathinStrongAstaxanthinMechanismastragalinLimitedastragaloside ivStrongatractylenolide iLimitedatractylenolide iiLimitedatractylenolide iiiLimitedaucubinLimited
B(46 compounds)
Bacopa extract standardizedModeratebacopaside iiModeratebacoside aLimitedbacoside bLimitedbaicaleinModeratebaicalinModerateBanaba Leaf ExtractStrongBCAAMechanismBcaasMechanismBeetroot extractMechanismBeetroot nitrateMechanismberbamineLimitedBerberineStrongBerberineMechanismbergaptenLimitedbeta- hydroxybutyrateModerateBeta-AlanineMechanismbeta-caryophylleneLimitedbeta-ecdysteroneModeratebeta-elemeneLimitedBeta-glucansMechanismBeta-sitosterolMechanismBetaineMechanismBetaine anhydrousMechanismBetaine HClMechanismBetaine NitrateLimitedbetulinic acidLimitedBicarbonateMechanismBifidobacterium ProbioticMechanismBilberry ExtractMechanismbilobetinLimitedbiochanin aStrongBiotinModeratebisabololLimitedbisdemethoxycurcuminLimitedBlack Seed OilLimitedBoronLimitedBoswelliaLimitedBoswellia AKBA standardizedMechanismboswellic acidLimitedboswellic acidsModerateBPC-157MechanismBromelainMechanismBurdock RootLimitedbutylidenephthalideLimitedbutyrateModerate
C(64 compounds)
CacaoModeratecafestolLimitedcaffeic acidLimitedCaffeineModeratecaffeine l-theanineStrongCalciumMechanismcalcium d-glucarateStrongcalycosinLimitedCannabidiolModerateCapsaicinMechanismCarnitine L TartrateLimitedcarnosic acidLimitedcarnosolModeratecarvacrolModeratecaryophyllene oxideLimitedcatalpolStrongcatechinLimitedCatuabaLimitedCBGLimitedcelastrolLimitedcepharanthineLimitedchamazuleneLimitedChamomileMechanismcharantinStrongchicoric acidLimitedChlorellaMechanismchlorogenic acidStrongCholineMechanismChondroitinMechanismChromiumMechanismchromium picolinateLimitedCimifugosideLimitedcinnamaldehydeStrongCinnamon extractMechanismCiticoline / CDP-cholineMechanismcitronellalLimitedCitrulline MalateMechanismCJC-1295MechanismCoconut OilStrongCoconut Water PowderModerateCoenzyme AStrongCoenzyme Q10MechanismCoenzyme Q10MechanismCollagen PeptidesMechanismcolumbamineStrongcolumbinLimitedcommipheric acidLimitedCopperModeratecoptisineStrongcordycepinLimitedCordycepsMechanismcordyceps militarisModeratecorosolic acidStrongCreatineMechanismCreatine + Beta-AlanineModerateCreatine HClMechanismCreatine monohydrateMechanismcrocetinLimitedcrocinLimitedcryptotanshinoneLimitedCurcumin + piperineMechanismCurcumin phytosomeMechanismcurcumolLimitedcurdioneLimited
D(22 compounds)
D Aspartic AcidMechanismD-Chiro InositolLimitedD-MannoseMechanismD-RiboseLimiteddaidzeinLimiteddaidzinLimitedDandelion RootLimiteddaphnetinLimitedDeglycyrrhizinated LicoriceLimiteddemethoxycurcuminLimiteddeoxyelephantopinLimiteddeoxymiroestrolLimiteddesmethoxyyangoninLimitedDevils Claw ExtractMechanismDHEAMechanismDietary NitratesModerateDigestive enzymesMechanismdihydrokavainLimiteddihydromethysticinLimiteddiindolylmethaneStrongdiosgeninStrongdiosminLimited
E(26 compounds)
EAA BlendMechanismEaa Essential Amino AcidsMechanismEchinaceaModerateechinacosideLimitedEGCGStrongEGCG + CaffeineModerateElectrolyte BlendModerateElectrolyte MixMechanismElectrolytes - Magnesium BlendModerateelemicinLimitedelephantopinLimitedEleuthero ExtractLimitedeleutheroside bLimitedeleutheroside eLimitedellagic acidModerateembelinLimitedemodinLimitedepicatechinLimitedepicatechin gallateModerateepigallocatechinLimitederinacinesLimitedesculetinLimitedEstrogen Balance StackMechanismeugenolLimitedexogenous ketonesModerateExtended-release melatoninMechanism
F(15 compounds)
G(42 compounds)
GABA (Oral)ModerategalanginLimitedGalantamineMechanismgallic acidLimitedgallocatechinLimitedGarcinia Cambogia ExtractLimitedgarcinolLimitedGarlic Aged ExtractModerateGarlic ExtractModerateGelatinLimitedgenisteinLimitedGHK-CuModerategingerolModerateGingerolsModerateGinkgo Biloba ExtractMechanismGinkgo Extract EGb 761Moderateginkgolide bModerateGinkgolidesModerateginsenoside rb1Strongginsenoside rg1Limitedginsenoside rg3LimitedGinsenosidesModerateGlucomannanMechanismglucomoringinModerateGlucosamineMechanismGlutamineMechanismGlutathioneMechanismGlycerolModerateGlycinate Magnesium ComplexMechanismGlycineModerateGlycine (Sleep Use)Moderateglycyrrhetinic acidStrongGlycyrrhizinModerateGlycyrrhizin (Isolated)ModerateGrape Seed ExtractMechanismGraviola (Annona muricata)LimitedGreen Tea EGCG IsolatedStrongGreen tea extract / EGCGStrongguggulsteroneLimitedgurmarinLimitedgymnemageninLimitedgymnemic acidLimited
H(16 compounds)
I(14 compounds)
J(1 compound)
K(7 compounds)
L(25 compounds)
L NorvalineMechanismL-CarnitineMechanismL-CitrullineMechanismL-theanineModerateL-Theanine (Sleep Use)ModerateL-TyrosineMechanismLactobacillus ProbioticMechanismlagerstroeminStrongLavenderModerateLavender ExtractMechanismlawsoneLimitedLecithinMechanismLemon balmMechanismLemon Balm ExtractMechanismLeucineMechanismLevodopaStrongLicorice RootLimitedligustilideLimitedlinaloolLimitedLithium OrotateLimitedloganinLimitedLumbrokinaseLimitedLuteinMechanismluteolinModerateLycopeneMechanism
M(38 compounds)
Maca Root ExtractMechanismMacamidesModeratemadecassic acidLimitedmadecassosideLimitedMagnesiumModeratemagnesium citrateMechanismMagnesium glycinateMechanismMagnesium OxideMechanismMagnesium ThreonateLimitedmagnoflorineLimitedmagnololLimitedManganeseModeratemangiferinStrongmangiferin aglyconeStrongmangostinLimitedMarshmallow RootLimitedMatchaMechanismmatrineLimitedMCT OilMechanismMelatoninStrongMentholModeratemesembrenoneLimitedmesembrineLimitedMetformin Natural ComparisonStrongmethyl eugenolLimitedMethylcobalaminModeratemethyleugenolLimitedMethylfolateMechanismMethylliberineMechanismmethysticinLimitedmomordicoside kStrongmorinLimitedmorronisideLimitedMSMLimitedMucuna pruriensMechanismmulberroside aLimitedmyricetinModeratemyristicinLimited
N(16 compounds)
NACMechanismNAD+StrongNADHLimitednaringeninModeratenaringinStrongNattokinaseMechanismneoandrographolideLimitednerolidolLimitedNiacinMechanismNiacinamideStrongNicotinamide MononucleotideLimitedNicotinamide ribosideStrongNicotinamide ribosideMechanismnicotineLimitedNicotinic AcidLimitedNutmeg (Myristica fragrans)Limited
O(18 compounds)
oleaceinLimitedOleamideLimitedoleanolic acidMechanismoleocanthalLimitedoleuropeinStrongOlive Leaf ExtractMechanismOmega-3 DHA-DominantModerateOmega-3 EPAStrongOmega-3 EPA-DominantModerateOmega-3 fatty acidsStrongononinLimitedOral rehydration saltsMechanismOregon Grape RootModerateornithineModerateOrotic AcidLimitedostholeLimitedoxymatrineLimitedoxyresveratrolLimited
P(47 compounds)
paeoniflorinLimitedpaeonolLimitedpalmatineStrongPalmitoylethanolamideModeratePanax Ginseng ExtractMechanismPanax Red GinsengModeratePanax White GinsengModeratePantethineModeratePapainMechanismPassionflowerMechanismPassionflower ExtractMechanismPassionflower Extract (Standardized)LimitedPau d'ArcoLimitedPeppermint OilMechanismPhenylalanineMechanismPhloretinMechanismphosphatidic acidModeratePhosphatidylcholineMechanismPiperineMechanismpiperlongumineMechanismPlant SterolsStrongplumbaginLimitedPolicosanolMechanismPomegranate ExtractMechanismPotassiumStrongPotassium electrolytesMechanismPQQMechanismPregnenoloneLimitedProanthocyanidinsModerateProbiotic MultistrainStrongProbioticsMechanismProbiotics - Bifidobacterium spp.ModerateProbiotics - Lactobacillus spp.ModerateprolineModeratepropionateModerateProtodioscinModeratepsoralenLimitedPsyllium huskMechanismPT-141 (Bremelanotide)ModeratepterostilbeneLimitedpuerarinStrongPumpkin seed oilMechanismpunicalaginModerateputrescineModeratePycnogenolMechanismPygeumModeratePyridoxal-5-phosphateStrong
Q(1 compound)
R(10 compounds)
S(38 compounds)
Saccharomyces boulardiiStrongSaffron ExtractStrongsafranalLimitedsafroleLimitedsaikosaponin aLimitedSalidrosideStrongSalvianolic acid BLimitedSAM-eMechanismSaw Palmetto ExtractLimitedSchisandra ExtractMechanismschisandrinLimitedschisandrin bModerateSchisandrinsModeratescopoletinLimitedSeleniumStrongSemaglutideStrongsenkyunolide aLimitedserineModerateSerrapeptaseMechanismshikoninStrongShilajitLimitedShilajit ExtractMechanismshogaolLimitedsilibininLimitedSilicaLimitedsilybinModeratesilychristinLimitedsilydianinLimitedSilymarinMechanismSkullcapMechanismSlippery ElmLimitedSodiumMechanismsodium bicarbonateMechanismSodium electrolytesMechanismspermidineLimitedSpirulinaLimitedstigmasterolLimitedSulforaphaneMechanism
T(25 compounds)
Tanshinone IIALimitedTaurineStrongTaurine (Sleep Context)LimitedTaurine BlendModerateTB-500MechanismTestosterone Boosters GenericMechanismTestosterone Support StackMechanismtetrandrineLimitedTheacrineMechanismtheaflavinLimitedtheanineModeratethearubiginLimitedthujoneLimitedthymolModeratethymoquinoneLimitedtimosaponin aiiiLimitedTirzepatideStrongTrans-ResveratrolStrongtrigonellineStrongTrimethylglycineModerateTryptophanMechanismTUDCAMechanismturkesteroneModerateTurmeric Curcumin + PiperineModeratetyrosolLimited
U(8 compounds)
V(18 compounds)
valepotriatesLimitedValerenic AcidModeratevalerenolLimitedValerian Extract (Standardized)LimitedValerian Root ExtractStrongValineStrongverbascosideLimitedVinpocetineMechanismVitamin AMechanismvitamin b12MechanismVitamin B3ModerateVitamin B6StrongVitamin CMechanismVitamin DMechanismVitamin D3MechanismVitamin D3 + K2ModerateVitamin EMechanismVitamin K2Mechanism
W(8 compounds)
X(1 compound)
Y(3 compounds)
Evidence Tier Guide
Strong: Multiple high-quality human trials with consistent findings.
Moderate: Several human trials with generally positive findings.
Limited: Few human trials, small samples, or mixed results.
Mechanism: Only mechanistic or animal data. No solid human trials.
Learning context
How this concept connects to supplement decisions
Search herbs and compounds by evidence grade, from human clinical support to mechanism-only data. Compare what has real evidence with what remains preliminary. Learning pages explain the reasoning layer behind the herb and compound library. They are designed to make mechanisms, evidence quality, safety tradeoffs, and product claims easier to interpret.
Use Supplement Evidence Lookup to build better questions before choosing a supplement: what outcome is being targeted, what mechanism is claimed, what human evidence exists, what dose was studied, and what risks could change the answer for a specific person?
Mechanistic plausibility is useful, but it should be weighed against trial design, safety history, product quality, and the possibility that a simpler intervention may be more appropriate.