Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Cinnamon Extract
Insulin sensitivity support; safety screen: liver disease; anticoagulant medication caution; pregnancy high dose caution.
Use extra caution — Cassia cinnamon can contain coumarin; avoid aggressive high dose chronic use with liver concerns. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·D Preliminary
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- Cassia cinnamon can contain coumarin; avoid aggressive high-dose chronic use with liver concerns.
- Profile context
- GLUT4
Quick stats
- Evidence level
- Preliminary evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- GLUT4
Safety
Safety & Cautions
Cassia cinnamon can contain coumarin; avoid aggressive high dose chronic use with liver concerns.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Moderate Caution
110 flagged pairingsBlood-sugar lowering
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence Summary
Profile-wide ·D PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Glucose Uptake Enhancement · AMPK Pathway Activation · Metabolic Regulation
Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.
Safety boundary: Safety note available — Cassia cinnamon can contain coumarin; avoid aggressive high dose chronic use with liver concerns.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Cinnamon Extract has a preliminary evidence rating.
General wellnessGeneral wellness
Citation density
1.0
Sources
1
Effects
1
Research recency
Mixed recency
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · Phytother Res · 2024 Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | — | PubMed → |
How Cinnamon Extract Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Cinnamon Extract Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Glucose Uptake Enhancement
- AMPK Pathway Activation
- Metabolic Regulation
- Carbohydrate Digestion Inhibition
- Insulin Sensitivity Modulation
- Glucose Metabolism Support
Guides that use Cinnamon Extract
Condition guides
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Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Related alternatives
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Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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