Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Citrulline Malate
High rep performance; blood flow support; safety screen: hypotension; nitrate/PDE5 medication review.
Review needed — May lower blood pressure; review with nitrates, PDE5 inhibitors, or hypotension. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·D Preliminary
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- May lower blood pressure; review with nitrates, PDE5 inhibitors, or hypotension.
- Profile context
- nitric oxide pathways, urea cycle
Quick stats
- Evidence level
- Preliminary evidence
- Typical onset
- Varies by prep
- Safety rating
- Review needed: Safety review pending
- Best for
- Nitric Oxide Pathways, Urea Cycle
- Avoid / review if
- Limited Data.
Safety
Safety & Cautions
May lower blood pressure; review with nitrates, PDE5 inhibitors, or hypotension.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Interaction-AwareMedication or interaction context is explicitly noted.
Evidence Summary
Profile-wide ·D PreliminaryEvidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Mitochondrial Support · Vascular Function Support · Endothelial Function Support
Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.
Safety boundary: Safety note available — May lower blood pressure; review with nitrates, PDE5 inhibitors, or hypotension.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Citrulline Malate has a preliminary evidence rating.
PerformanceRecovery
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Randomized controlled trial
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a randomized controlled trial, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 1 is a human trial.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · Nutrients · 2024 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | — | PubMed → |
How Citrulline Malate Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Citrulline Malate Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- powder or capsule
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Mitochondrial Support
- Vascular Function Support
- Endothelial Function Support
- Endothelial Function
Continue exploring
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Compare & Sourcing
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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