Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
EGCG + Caffeine
Compound profile with evidence, safety, and practical fit.
Use extra caution — Safety evidence: concentrated green tea catechin supplements at or above 800 mg/day EGCG raised liver enzyme concern, with fasting exposure relevant; lower dose risk remains uncertain. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate
At a glance
From this profile's structured data- Evidence
- Grade B
- Safety
- Safety evidence: concentrated green-tea catechin supplements at or above 800 mg/day EGCG raised liver-enzyme concern, with fasting exposure relevant; lower-dose risk remains uncertain.
- Profile context
- stimulant_CNS, glucose_AMPK
Quick stats
- Evidence level
- Moderate evidence
- Typical onset
- Varies by prep
- Safety rating
- Use extra caution: Use caution
- Best for
- Stimulant CNS, Glucose AMPK
- Avoid / review if
- Previous Green Tea Extract Associated Liver Injury, High Dose EGCG Extract Use Without Clinical Supervision, Especially When Fasting.
Botanical Context
Source botanicals and comparison guides related to EGCG + Caffeine.
Safety
Safety & Cautions
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Interaction-AwareMedication or interaction context is explicitly noted.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
- Safety evidence
- concentrated green-tea catechin supplements at or above 800 mg/day EGCG raised liver-enzyme concern, with fasting exposure relevant; lower-dose risk remains uncertain
- Who should avoid this?
- Previous Green Tea Extract Associated Liver Injury; High Dose EGCG Extract Use Without Clinical Supervision; Especially When Fasting.
- Talk to a professional if
- you use relevant medications, you are pregnant or breastfeeding, you have a condition named in this safety summary.
Caffeine adds dose-dependent sleep, anxiety-like, and cardiovascular effects; pregnancy and medication-specific safety require review.
Evidence Summary
Profile-wide ·B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Metabolic Regulation · Vascular Function Support · AMPK Signaling
Research maturity: Established research — main contexts: Stimulant CNS · Glucose AMPK
Safety boundary: Safety note available — Safety evidence: concentrated green tea catechin supplements at or above 800 mg/day EGCG raised liver enzyme concern, with fasting exposure relevant; lower dose risk remains uncertain.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
EGCG + Caffeine has a moderate evidence rating.
General wellnessGeneral wellness
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta analysis
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a meta analysis, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
The effects of green tea on weight loss and weight maintenance: a meta-analysis PubMed · Int J Obes (Lond) · 2009 Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | — | PubMed → |
How EGCG + Caffeine Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How EGCG + Caffeine Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Metabolic Regulation
- Vascular Function Support
- AMPK Signaling
- Glucose Metabolism Support
Guides that use EGCG + Caffeine
Condition guides
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Related research paths
Related Herbs
Botanicals connected by the same goals, effects, or research topics.
Related Guides
Deeper context, comparisons, and practical research paths.
Related Safety Pages
Safety checks and cautions relevant to this decision.
Related Articles
Deeper context, comparisons, and practical research paths.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for EGCG + Caffeine
Independent database mapping — evaluated separately from safety and efficacy scores.
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Related alternatives
Herbs for similar conditions
Tradeoffs
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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