Herb Profile
Gotu Kola Centella Asiatica
Botanical profile with evidence, safety, and practical fit.
Last reviewed: •3 human studies cited
B ModerateUse extra caution — Generally well tolerated; mild GI upset or drowsiness possible; rare photosensitivity; avoid in pregnancy/breastfeeding; caution with sedatives and liver conditions at high doses. Details
- Evidence
- Moderate Human Evidence
- Typical onset
- Varies by prep
- Safety rating
- High caution
- Best for
- Microcirculation, Collagen Pathways, Vascular Function, Cognitive Support
- Avoid / review if
- Sedatives
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Gotu Kola Centella Asiatica
The Hippie Scientist
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Safety & Cautions
Generally well tolerated; mild GI upset or drowsiness possible; rare photosensitivity; avoid in pregnancy/breastfeeding; caution with sedatives and liver conditions at high doses.
28%
High caution — review carefully
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- - Sedatives
Safety classifications
- - Liver-Sensitive: Liver-related caution language appears in the profile.
- - Pregnancy/Breastfeeding Caution: Pregnancy or breastfeeding caution language is present.
Full safety note
- - Generally well tolerated; mild GI upset or drowsiness possible; rare photosensitivity; avoid in pregnancy/breastfeeding; caution with sedatives and liver conditions at high doses.
Safety labels
- - Liver-Sensitive
- - Pregnancy/Breastfeeding Caution
Evidence-based safety
Caution when combined
These pairings share a flagged risk mechanism. They are additive-effect cautions derived from contraindication data, not confirmed clinical interactions. Consult a clinician before combining.
Moderate Caution
68 flagged pairingsSedation / CNS depression
Moderate Caution
68 flagged pairingsSedation / CNS depression
Browse the grouped cautions below. The list scrolls inside this card when long.
Sedation / CNS depression
- American Yellow Lotus
- Artemisia Absinthium
- Ashwagandha (Withania somnifera)
- Bacopa
- Black Seed
- Black Tea
- Blue Lotus
- Calamus
- Catuba
- Celastrus Paniculatus
- Chamomile
- Chinese Skullcap
- Coriandrum Sativum
- Corydalis
- Cymbopogon Citratus
- Damiana
- California Poppy
- Eucalyptus
- Gastrodia
- Glycine
- Hops
- Hypericum Perforatum
- Jatamansi
- Jujube
- Lavender
- Lavender
- Lavender Extract
- Lemon balm
- Lemon Balm Extract
- Lemon Verbena
- Lemongrass
- Lobelia Inflata
- Longan
- Magnolia
- Melatonin
- Lemon Balm
- Milk Oats
- Mugwort
- Muira Puama
- Myristica Fragrans
- Nicotiana Glauca
- Nicotiana Tabacum
- Oatstraw
- Ocimum Basilicum
- Parsley
- Passionflower
- Passionflower
- Passionflower Extract
- Passionflower Extract (Standardized)
- Kava
- Polygala
- Poria
- Raspberry Leaf
- Sage
- Schisandra Berry
- Schisandra Chinensis
- Scutellaria Baicalensis
- Skullcap
- Shankhpushpi
- Sophora Flavescens
- theanine
- Valeriana officinalis
- Valerian Extract (Standardized)
- Valerian Root Extract
- Valerian
- Verbena Officinalis
- Ashwagandha
- Wormwood
Evidence Summary
Evidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate Human Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Oxidative Stress Modulation · Neurotransmitter Modulation · Vascular Function Support
Research maturity: Preliminary or mixed — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Generally well tolerated; mild GI upset or drowsiness possible; rare photosensitivity; avoid in pregnancy/breastfeeding; caution with sedatives and liver conditions at high doses.
This profile cites 3 human studies.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
A
Strong
Multiple RCTs, consistent direction, adequate effect size
B
Moderate
Some RCTs or consistent observational data in humans
C
Preliminary / Mixed
Animal or in-vitro only, or conflicting human data
D
Traditional / Theoretical
Traditional use only; no controlled human trials
Clinical Study Summaries (1)Cited studies informing this profile. RCTs and reviews shown first.
| Study | Type | Sample | Source |
|---|---|---|---|
Requires manual source normalization to PMID, DOI, PMC, or authoritative URL. | — | — | Source → |
Dosing & Timing
Dose guidance
300 600 mg/day standardized extract; traditional dried herb often 2 4 g/day
How Gotu Kola Centella Asiatica Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Gotu Kola Centella Asiatica Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & Biological Pathways
Preclinical pathways
Proposed mechanisms from in vitro and animal research; these do not confirm clinical outcomes in humans.
Oxidative Stress ModulationNeurotransmitter ModulationVascular Function SupportStress Response ModulationNeuroprotective Activity
Active Compounds
Key constituents studied in Gotu Kola Centella Asiatica, with full pharmacology and safety profiles.
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Review available sources for Gotu Kola Centella Asiatica
Independent database mapping — evaluated separately from safety and efficacy scores.
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Affiliate-ready sourcing
Gotu Kola product picks
Affiliate recommendations for Gotu Kola Centella Asiatica. Review safety, dose, and product quality before buying.
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Product Form & Quality Guidelines
When sourcing Gotu Kola Centella Asiatica, verify the label for:
- Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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Botanical profile context
How to interpret Gotu Kola Centella Asiatica
Gotu Kola dosage ranges, effects, drug interactions, and harm-reduction safety guide for microcirculation. Moderate Human Evidence research evidence. Use this herb profile as a starting point for evidence review, not as a recommendation to start a new supplement. Botanical products can vary by plant part, extract ratio, standardization, dose, and contaminant testing, so two labels with the same common name may not behave the same way.
When reviewing Gotu Kola Centella Asiatica, compare the traditional-use context against the human evidence, mechanism notes, and safety cautions. Pay special attention to pregnancy, breastfeeding, liver or kidney disease, blood-pressure effects, sedation, stimulation, anticoagulant use, antidepressants, and any prescription medication overlap.
For product decisions, prefer transparent labels, named extracts, clear serving sizes, and third-party quality testing. Avoid treating a long list of possible mechanisms as proof that an herb will solve a specific condition.