Related Compounds
Compounds connected by the same goals, effects, or research topics.
Herb Profile
Magnolia
Magnolia officinalis
Needs dedicated human sleep/anxiety evidence before claims.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·D Preliminary
Use extra caution — Safety and sedation/drug interaction review required. Details
- Evidence
- Preliminary Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- Sleep, Stress, Cognitive function, Hormonal effects
- Avoid / review if
- Sedatives, Anticoagulants
At a glance
From this profile's structured data- Evidence
- Grade D
- Safety
- Safety and sedation/drug-interaction review required.
- Profile context
- sleep, stress
Safety
Safety & Cautions
Safety and sedation/drug interaction review required.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
- Interaction-AwareMedication or interaction context is explicitly noted.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Sedatives
- Anticoagulants
Safety classifications
- Interaction-Aware: Medication or interaction context is explicitly noted.
Full safety note
- Safety and sedation/drug interaction review required.
Safety labels
- Interaction-Aware
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Moderate Caution
68 flagged pairingsSedation / CNS depression
Moderate Caution
68 flagged pairingsSedation / CNS depression
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Sedation / CNS depressionCertainty: Theoretical
Data provenance recorded for 68 of 68 pairings in this mechanism group.
- American Yellow Lotus — Theoretical interaction certainty
- Artemisia Absinthium — Theoretical interaction certainty
- Ashwagandha (Withania somnifera) — Theoretical interaction certainty
- Bacopa — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
- Black Tea — Theoretical interaction certainty
- Blue Lotus — Theoretical interaction certainty
- Calamus — Theoretical interaction certainty
- Catuba — Theoretical interaction certainty
- Celastrus Paniculatus — Theoretical interaction certainty
- Chamomile — Theoretical interaction certainty
- Chinese Skullcap — Theoretical interaction certainty
+56 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Early signal that needs stronger human replication before practical claims.
PreliminaryPreliminary Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Neurotransmitter Modulation · Hormonal Signaling Context · Stress Response Modulation
Research maturity: Preliminary research — Early findings are not treated as established consumer benefit.
Safety boundary: Safety note available — Safety and sedation/drug interaction review required.
This profile cites 3 human studies.
Study design details
Evidence Grade
Grade D: Preliminary / Theoretical Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 3 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (4)2 human evidence sources · 1 human trial · ~68 participants across 1 human evidence source with reported N · Consistency not yet classifiable
Filter by study class
Showing 4 of 4 studies.
What the evidence actually shows
This table contains 4 structured sources, including 2 human evidence sources; 1 is a human trial. Across 1 human evidence source with a reported sample size, the approximate participant total is 68; overlapping publications may include some of the same people.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | A 2024 systematic review of magnolia neolignans for Alzheimer-related outcomes found the evidence base to be predominantly preclinical. It does not establish clinical benefit of magnolia bark in people. | PubMed → |
Opat S et al. · Blood Adv · 2023 Background | Controlled trial Compares an intervention with a control group but may lack random assignment or other safeguards of a strong randomized trial. | n=68 | — | — | — | — | — | PubMed → |
Safety and Toxicology of Magnolol and Honokiol Sarrica A et al. · Planta Med · 2018 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Sakamoto S et al. · J Nat Med · 2025 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- No standardized dose
- Magnolia officinalis neolignans; fetched abstract unavailable. No dose claim from fetched source.
How Magnolia works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Magnolia Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Neurotransmitter Modulation
- Hormonal Signaling Context
- Stress Response Modulation
Active Compounds
Key constituents studied in Magnolia, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Guides that use Magnolia
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
Help improve this profile
Was this useful for your research?
These controls record only the page and the structured choice you make when analytics consent is enabled. Please don’t include personal medical information in research requests.
Was this evidence summary clear?
Did you find what you were researching?
Free safety checklist
Get the Magnolia research notes
Evidence summaries, dosing context, and safety updates for this herb — straight to your inbox.
We use your email to send the checklist and occasional evidence-first supplement updates. Unsubscribe anytime. Privacy policy.