Related Compounds
Compounds connected by the same goals, effects, or research topics.
Herb Profile
Grape
Vitis vinifera
Grape (Vitis vinifera) carries an editorial Grade B rating, but the studies recorded on this profile do not demonstrate that grade.
Last reviewed: •3 sources citedReport a correctionProfile-wide ·Unassigned
Standard caution — Generally safe Details
- Evidence
- Editorial Grade Not Demonstrated By Recorded Studies
- Typical onset
- Varies by prep
- Safety rating
- Low caution
- Best for
- Antioxidant, Cardiovascular, Anti Inflammatory, Stress
- Avoid / review if
- Anticoagulants
At a glance
From this profile's structured data- Evidence
- Editorial grade not demonstrated by recorded studies
- Safety
- Generally safe
- Profile context
- antioxidant, cardiovascular, anti_inflammatory
Safety
Safety & Cautions
Generally safe
Standard caution
Caution level: Standard. No specific caution categories were detected in the source record.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Anticoagulants
Full safety note
- Generally safe
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Treat this profile as unresolved until source review is complete.
Needs reviewEditorial Grade Not Demonstrated By Recorded Studies
Human clinical evidence: Not the primary signal
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Vascular Function Support
Research maturity: Theoretical / mechanistic research — Mechanistic or unresolved evidence is kept separate from established human outcomes.
Safety boundary: Safety note available — Generally safe
This profile cites 3 human studies.
Study design details
Evidence Grade
Evidence grade not assigned
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Narrative review
- Risk of Bias
- High
- Consistency
- Not assessed
Strongest recorded design is a narrative review, drawn from 3 recorded studies, none of which measured an outcome in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (3)0 human evidence sources · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 3 structured sources, including 0 human evidence sources; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Gawish AS et al. · J Periodontal Implant Sci · 2024 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Selected Food/Herb-Drug Interactions: Mechanisms and Clinical Relevance Amadi CN et al. · Am J Ther · 2018 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Grape Pomace Valorization: A Systematic Review and Meta-Analysis Antonić B et al. · Foods · 2020 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- Dose guidance
- 150 300 mg extract
How Grape works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Grape Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Vascular Function Support
- Stress Response Modulation
- Endothelial Function Support
Active Compounds
Key constituents studied in Grape, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Guides that use Grape
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Continue comparing
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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