Related Compounds
Compounds connected by the same goals, effects, or research topics.
Compound Profile
Andrographis
Andrographis has moderate human evidence for reducing upper respiratory tract infection symptoms.
Review needed — GI upset; rare allergic reactions. Details
Last reviewed: •1 source citedReport a correctionProfile-wide ·B Moderate
At a glance
From this profile's structured data- Evidence
- Grade B
- Safety
- GI upset; rare allergic reactions.
- Profile context
- NF-κB, immune response pathways
Quick stats
- Evidence level
- Moderate evidence
- Typical onset
- Varies by prep
- Safety rating
- Review needed: Safety review pending
- Best for
- NF κB, Immune Response Pathways
- Avoid / review if
- Pregnancy (Animal And Traditional Use Evidence Of Uterine Stimulant/Antifertility Effects), Known Acanthaceae Family Allergy, Anticoagulant/Antiplatelet Or Antihypertensive Therapy Without Monitoring
Safety
Safety & Cautions
GI upset; rare allergic reactions.
High caution
Caution level: High. Multiple caution categories apply, or the record uses avoid/contraindication language.
- Liver-SensitiveLiver-related caution language appears in the profile.
- Stimulant-Like ProfileStimulant-like or activating caution language is present.
- Anticoagulant CautionBleeding or anticoagulant-adjacent caution language is present.
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
- Angelica Sinensis — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Moderate Caution
191 flagged pairingsBlood-sugar lowering · Blood-pressure effects
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Blood-sugar loweringCertainty: Theoretical
Data provenance recorded for 110 of 110 pairings in this mechanism group.
- Acarbose — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Aloe Vera — Theoretical interaction certainty
- Alpha-Lipoic Acid — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Anemarrhena Asphodeloides — Theoretical interaction certainty
- Tarragon — Theoretical interaction certainty
- Ashoka — Theoretical interaction certainty
- Astragalus — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
- Bael — Theoretical interaction certainty
+98 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Blood-pressure effectsCertainty: Theoretical
Data provenance recorded for 81 of 81 pairings in this mechanism group.
- Agmatine sulfate — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Astaxanthin — Theoretical interaction certainty
- Astragalus Membranaceus — Theoretical interaction certainty
- Beetroot extract — Theoretical interaction certainty
- Berberis — Theoretical interaction certainty
- Bicarbonate — Theoretical interaction certainty
- Black Seed — Theoretical interaction certainty
- Black Seed Oil — Theoretical interaction certainty
+69 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence Summary
Profile-wide ·B ModerateEvidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Immune Signaling Modulation · NF KB Modulation
Research maturity: Established research — main contexts: NF κB · Immune Response Pathways
Safety boundary: Safety note available — GI upset; rare allergic reactions.
This profile cites 1 human study.
Evidence Strength
Confidence estimate based on the design quality and consistency of published clinical trials.
Andrographis has a moderate evidence rating.
General wellnessGeneral wellness
Citation density
0.5
Sources
1
Effects
2
Research recency
Mixed recency
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Systematic review
- Risk of Bias
- Low
- Consistency
- Not assessed
Strongest recorded design is a systematic review, drawn from 2 recorded studies, 2 in people.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (1)1 human evidence source · 0 human trials · Participant totals not consistently reported · Consistency not yet classifiable
What the evidence actually shows
This table contains 1 structured source, including 1 human evidence source; 0 are human trials.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
PubMed · Planta Med · 2004 Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | — | PubMed → |
How Andrographis Works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Andrographis Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Dosing
- Common form
- capsule or standardized extract
- No standardized dose
- Our source data records the usual product form for this ingredient but no studied dose. Preparations differ widely, so follow the standardization on the product you actually have and speak to a clinician before starting.
Mechanisms & biological pathways
Preclinical mechanism details from scientific profiles; these represent plausible pathways but do not guarantee clinical efficacy in humans.
- Inflammatory Signaling Modulation
- Immune Signaling Modulation
- NF KB Modulation
- Inflammatory
Guides that use Andrographis
Condition guides
Continue exploring
Related research paths
Related Herbs
Botanicals connected by the same goals, effects, or research topics.
Related Guides
Deeper context, comparisons, and practical research paths.
Related Safety Pages
Safety checks and cautions relevant to this decision.
Related Articles
Deeper context, comparisons, and practical research paths.
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Related alternatives
Herbs for similar conditions
Tradeoffs
Free safety checklist
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Sourcing options
Andrographis product picks
Recommendation status
Product recommendations are not shown for this profile because the current site safety and monetization policy does not permit them.
Product form & quality guidelines
When sourcing Andrographis, verify the label for:
- Standardized Extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-Party Testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form Bioavailability: Ensure the form matches evidence-supported configurations (e.g. chelated bisglycinate/glycinate for magnesium, micronized monohydrate for creatine) for optimal onset and digestion tolerance.
Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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