Related Compounds
Compounds connected by the same goals, effects, or research topics.
Herb Profile
Ginger Zingiber Officinale
Zingiber officinale
Ginger (Zingiber officinale) is best documented for nausea relief and digestive comfort, with additional evidence for anti inflammatory and antioxidant activity via COX/LOX and NF kB pathway modulation.
Last reviewed: •5 sources citedReport a correctionProfile-wide ·B Moderate
Use extra caution — Excellent general safety; high doses may cause heartburn or GI warming; mild blood thinning potential; caution with anticoagulants and additive turmeric/ginkgo stacks. Details
- Evidence
- Moderate Evidence
- Typical onset
- Varies by prep
- Safety rating
- Moderate caution
- Best for
- COX/LOX Pathways, Serotonin Receptors, Digestion, Nausea Support
- Avoid / review if
- Anticoagulants
At a glance
From this profile's structured data- Evidence
- Grade B
- Safety
- Excellent general safety; high doses may cause heartburn or GI warming; mild blood-thinning potential; caution with anticoagulants and additive turmeric/ginkgo stacks.
- Profile context
- COX/LOX pathways, serotonin receptors, digestion
Safety
Safety & Cautions
Excellent general safety; high doses may cause heartburn or GI warming; mild blood thinning potential; caution with anticoagulants and additive turmeric/ginkgo stacks.
Elevated caution
Caution level: Elevated. One caution category applies — read it before use.
Detailed safety fields
Pregnancy, breastfeeding, and contraindications
- Anticoagulants
Full safety note
- Excellent general safety; high doses may cause heartburn or GI warming; mild blood thinning potential; caution with anticoagulants and additive turmeric/ginkgo stacks.
Evidence-based safety
Caution when combined
Severity and certainty are shown separately. A high-priority caution can still be theoretical: these pairings are screened from shared contraindication mechanisms and are not automatically documented clinical interactions. Provenance identifies the source fields that produced each flag; it does not upgrade the certainty of the pairwise claim.
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
High-Priority Caution
147 flagged pairingsBleeding / anticoagulant risk
Representative pairings are shown below. Large mechanism groups are intentionally summarized to keep profiles focused and crawl-efficient.
Bleeding / anticoagulant riskCertainty: Theoretical
Data provenance recorded for 147 of 147 pairings in this mechanism group.
- aescin — Theoretical interaction certainty
- Aged Garlic Extract — Theoretical interaction certainty
- ajoene — Theoretical interaction certainty
- Ajwain — Theoretical interaction certainty
- Allicin — Theoretical interaction certainty
- Garlic — Theoretical interaction certainty
- American Ginseng Extract — Theoretical interaction certainty
- Andrographis — Theoretical interaction certainty
- Angelica Archangelica — Theoretical interaction certainty
- Angelica Dahurica — Theoretical interaction certainty
- Angelica Pubescens — Theoretical interaction certainty
- Angelica Root — Theoretical interaction certainty
+135 more pairings share this mechanism. Use the Safety Checker to review a specific combination.
Evidence
Evidence Summary
Evidence lens
Useful signal, but study design, dose, and population still matter.
ModerateModerate Evidence
Human clinical evidence: Present in source signals
Mechanistic / preclinical: Mechanism mapped — Inflammatory Signaling Modulation · Oxidative Stress Modulation · Neurotransmitter Modulation
Research maturity: Established research — Long Term Human Evidence May Be Limited.
Safety boundary: Safety note available — Excellent general safety; high doses may cause heartburn or GI warming; mild blood thinning potential; caution with anticoagulants and additive turmeric/ginkgo stacks.
This profile cites 5 human studies.
Study design details
Evidence Grade
Grade B: Moderate Evidence
Evaluation of methodological rigor, population reach, and evidence alignment.
- Design Match
- Meta-analysis
- Risk of Bias
- Low
- Consistency
- Consistent
Strongest recorded design is a meta-analysis, drawn from 12 recorded studies, 9 in people. No disagreement is recorded across them.
How evidence grades work
Each grade reflects the strength and consistency of published human evidence — not marketing claims. Grades are based on study count, design quality, effect size, consistency, and recency.
- Strong
- Multiple RCTs, consistent direction, adequate effect size
- Moderate
- Some RCTs or consistent observational data in humans
- Preliminary / Mixed
- Animal or in-vitro only, or conflicting human data
- Traditional / Theoretical
- Traditional use only; no controlled human trials
Clinical Study Summaries (11)4 human evidence sources · 1 human trial · Participant totals not consistently reported · Consistency not yet classifiable
Filter by study class
Showing 11 of 11 studies.
What the evidence actually shows
This table contains 11 structured sources, including 4 human evidence sources; 1 is a human trial.
| Study | Design | N | Dose | Duration | Population | Outcome | Result & magnitude | Source |
|---|---|---|---|---|---|---|---|---|
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | Ginger capsules used with standard antiemetics reduced severe acute nausea and high-grade vomiting in pooled analyses. | PubMed → |
Background | Meta-analysis Statistically combines results from multiple eligible studies; confidence still depends on the quality, consistency, and directness of those studies. | — | — | — | — | — | Pooled randomized evidence showed improvement in CRP, TNF-alpha, IL-6, total antioxidant capacity, MDA, and SOD. | PubMed → |
Background | Systematic review Uses a predefined method to find and evaluate relevant studies, but may or may not pool their results statistically. | — | — | — | — | — | The review synthesizes RCT evidence across cardiovascular risk biomarkers and supports endpoint-specific rather than blanket cardiovascular claims. | PubMed → |
Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial PubMed · Obstet Gynecol · 2001 Background | Randomized controlled trial Randomly assigns participants to interventions or controls, reducing many sources of bias when the trial is conducted well. | — | — | — | — | — | — | PubMed → |
Ayustaningwarno F et al. · Front Nutr · 2024 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Effect of Ginger on Inflammatory Diseases Ballester P et al. · Molecules · 2022 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Show 5 more studies
Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe) Mao QQ et al. · Foods · 2019 Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | — | PubMed → |
Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | Across a large umbrella evidence base, ginger was consistently associated with reductions in inflammatory markers such as CRP and IL-6 and favorable changes in selected metabolic outcomes. | PubMed → |
Ginger for treating nausea and vomiting: an overview of systematic reviews and meta-analyses Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | Higher-level evidence supports ginger as useful in some nausea/vomiting settings, but results vary substantially by clinical indication. | PubMed → |
Background | Narrative review Summarizes selected literature without the full prespecified search and selection methods of a systematic review. | — | — | — | — | — | Synthesized meta-analytic evidence identifies recurring positive signals for inflammation, metabolic markers, oxidative stress, and pregnancy-associated nausea. | PubMed → |
Evolution of the mortality rate in the age class of 75-84 years worldwide PubMed · Acta Cardiol · 2002 Background | Other / unclear The study design is not yet classified clearly enough to infer its place in the evidence hierarchy. | — | — | — | — | — | — | PubMed → |
Dosing & Timing
- Dose guidance
- 500 2,000 mg/day standardized extract; fresh ginger equivalent often around 3 4 g/day
How Ginger Zingiber Officinale works
Simplified mechanism pathway based on preclinical and pharmacological evidence. Does not confirm clinical efficacy.
Mechanism Pathway — How Ginger Zingiber Officinale Works
CompoundTarget / ReceptorMechanismEffect / Outcome
Mechanisms & biological pathways (preclinical)
- Inflammatory Signaling Modulation
- Oxidative Stress Modulation
- Neurotransmitter Modulation
- NF KB Modulation
Active Compounds
Key constituents studied in Ginger Zingiber Officinale, with full pharmacology and safety profiles.
Compare related active botanicals
Explore botanicals with similar chemistry, effects, or safety considerations in the Botanical Activity Atlas.
Guides that use Ginger Zingiber Officinale
Goal guides
Condition guides
Compare & Sourcing
Compare side-by-side tradeoffs or verify active marker guidelines.
Sourcing options
Ginger product picks
Recommendation status
Product recommendations are not shown for this profile because the current site safety and monetization policy does not permit them.
Product form & quality guidelines
When sourcing Ginger Zingiber Officinale, verify the label for:
- Standardized extract: Confirm active content percentages on the supplement facts panel (e.g. standardized to specific marker compounds) rather than simple raw herb weights.
- Third-party testing: Look for independent purity labels (USP, NSF, ConsumerLab, or Eurofins) to ensure the product is free from heavy metals, solvents, and contaminants.
- Form bioavailability: Ensure the form matches evidence-supported configurations (e.g. standardized active extracts like bacosides, withanolides, or curcuminoids) for optimal onset and digestion tolerance.
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Safety first · Harm reduction
This information is educational and not medical advice. Start low, avoid risky combinations, and consult a licensed clinician before making health decisions—especially if you use medications, have diagnosed conditions, or are pregnant/breastfeeding.
Learn how we evaluate confidence, safety, and intensity on the methodology page.
Editorial Review
Checked against primary sources, cited evidence, and contraindication language before publication. Evidence claims, safety language, and affiliate modules are reviewed independently. Not personal medical advice.
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