Compound research library

Aged garlic extract reduces systolic and diastolic blood pressure in hypertensive patients.

Decision ready summary: Alpha Lipoic Acid is best framed for diabetic neuropathy symptoms; oxidative stress; glucose metabolism support; safety screen: hypoglycemia risk; thyroid medication timing; thiamine deficiency/alcohol use.

Andrographis has moderate human evidence for reducing upper respiratory tract infection symptoms.

Decision ready summary: Bacopa extract standardized is best framed for memory acquisition; cognitive performance over time; attention support; safety screen: pregnancy; thyroid medication monitoring; GI intolerance.

Bacopa triterpenoid saponin associated with nootropic activity and kinase linked neuroprotective signaling.

Bacopa saponin fraction associated with cognitive signaling support.

Bacopa saponin fraction linked to cognition related signaling.

Decision ready summary: Berberine is best framed for fasting glucose support; insulin resistance context; triglyceride/LDL support; safety screen: pregnancy; breastfeeding; diabetes medications; CYP/P gp medication review.

Curcuminoid linked to inflammatory pathway suppression and redox signaling.

Decision ready summary: Black seed / Nigella sativa is best framed for metabolic markers; inflammation support; allergic rhinitis support; safety screen: pregnancy high dose caution; anticoagulants; low blood pressure.

Compound profile with evidence, safety, and practical fit.

Decision ready summary: Caffeine is best framed for alertness; reaction time; fatigue reduction; safety screen: anxiety disorder; uncontrolled hypertension; arrhythmia.

Compound profile with evidence, safety, and practical fit.

Human RCT evidence supports L carnitine L tartrate for exercise recovery and muscle damage markers in trained or active adults; fat loss claims are not established.

Sesquiterpenoid from zedoary associated with inflammatory pathway modulation.

May improve insulin sensitivity and ovulation; limited evidence.

Curcuminoid analog associated with inflammatory and antioxidant response pathways.

Compound profile with evidence, safety, and practical fit.

Echinacoside is a phenylethanoid glycoside found in Echinacea and Cistanche related materials. It is mainly characterized by antioxidant, neuroprotective, and anti inflammatory preclinical research rather than strong human intervention data.

Decision ready summary: EGCG is best framed for fat oxidation support; cardiometabolic markers; antioxidant polyphenol intake; safety screen: liver disease; high dose fasting use; stimulant sensitivity.

Compound profile with evidence, safety, and practical fit.

Electrolyte blends are most useful for rehydration when sweat loss, heat exposure, diarrhea, vomiting, or prolonged exercise increases sodium and fluid needs; they should not be treated as a fat loss or energy shortcut.

Magnesium blends support deficiency correction and neuromuscular function, but cramp evidence is mixed.

Cyathane diterpenoids from lion's mane mycelium studied for nerve growth factor and neurotrophic signaling.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Garlic modestly reduces total cholesterol and blood pressure.

Aged garlic extract has moderate human evidence for blood pressure and modest lipid improvements with a different constituent profile than raw garlic.

Decision ready summary: Garlic Extract is best framed for blood pressure support; LDL/cholesterol context; cardiovascular risk factor support; safety screen: anticoagulants; planned surgery; bleeding disorder.

Compound profile with evidence, safety, and practical fit.

Gingerols are ginger phenolic constituents linked to pain/inflammation effects, with human evidence mostly through standardized ginger extracts rather than isolated gingerol dosing.

EGb 761 is a standardized Ginkgo biloba extract with moderate evidence for modest benefit in cognitive decline/dementia contexts.

Terpene lactone from Ginkgo biloba affecting platelet activating factor.

Ginkgolides are diterpene lactones in Ginkgo biloba extracts, especially relevant to platelet activating factor antagonism.

Glycine may support subjective sleep quality and bedtime relaxation without being a strong sedative.

Glycine has limited moderate evidence for subjective sleep quality improvements at bedtime.

Isolated/high dose EGCG has moderate metabolic evidence but important hepatotoxicity concerns at concentrated extract doses.

Decision ready summary: Green tea extract / EGCG is best framed for fat oxidation support; cardiometabolic markers; antioxidant polyphenol intake; safety screen: liver disease; high dose fasting use; stimulant sensitivity.

Human RCT evidence suggests holy basil extract may reduce stress and anxiety symptoms, though study size and replication are limited.

Improves insulin sensitivity and ovulatory function in PCOS.

Inositol has limited evidence for anxiety/panic outcomes, but sleep specific evidence is weak.

Inositol hexanicotinate is a flush free niacin form that is better tolerated but does not reliably reproduce nicotinic acid's lipid effects. Evidence supports caution against treating it as an equivalent niacin substitute.

Corrects iron deficiency anemia effectively.

Decision ready summary: L theanine is best framed for acute relaxation; calm focus; caffeine smoothing; safety screen: low blood pressure; sedative stacking caution.

L theanine has limited moderate evidence for sleep quality, especially stress related sleep disturbance.

Compound profile with evidence, safety, and practical fit.

Macamides is a fatty acid amides associated with maca. Evidence level: mixed.

Magnesium is most useful when low intake, deficiency risk, muscle tension, or sleep quality issues overlap.

Human evidence for magnesium exists broadly, but L threonate specific cognitive or sleep claims lack strong verified RCT support.

Decision ready summary: Melatonin is best framed for sleep onset latency; jet lag; circadian rhythm shift; safety screen: sedatives; pregnancy without clinician guidance; autoimmune conditions review.

MSM is a sulfur containing compound with limited to moderate evidence for modest osteoarthritis pain reduction.

Olive secoiridoid associated with NF κB and AMPK pathway modulation.

DHA supports brain development and may modestly benefit cognition.

High dose EPA significantly reduces major cardiovascular events.

EPA dominant omega 3 formulations have moderate evidence for depressive symptom reduction in some analyses.

Decision ready summary: Omega 3 fatty acids is best framed for triglyceride reduction; cardiovascular support; inflammation modulation; safety screen: bleeding disorder; anticoagulants at high dose; fish allergy.

Mulberry stilbene linked to carbohydrate processing and signaling effects.

Red ginseng has moderate human evidence for fatigue and modest erectile function outcomes, with product processing affecting ginsenoside profile.

White ginseng is less processed Panax ginseng with less extract specific evidence than red ginseng.

Standardized passionflower extract has limited human evidence for modest sleep/anxiety benefit.

Decision ready summary: Potassium is best framed for potassium deficiency; blood pressure support; electrolyte balance; safety screen: kidney disease; ACE inhibitors/ARBs; potassium sparing diuretics.

Bifidobacterium probiotics have moderate, strain specific evidence for IBS and digestive health outcomes.

Decision ready summary: Quercetin is best framed for allergy symptom context; inflammatory support; oxidative stress support; safety screen: kidney disease high dose; anticoagulants; CYP medication review.

Quercetin phytosome is a bioavailability enhanced quercetin formulation. Human outcome evidence remains limited, with small effects reported for vascular or inflammatory markers.

Decision ready summary: Resveratrol is best framed for cardiometabolic markers; endothelial function; oxidative stress markers; safety screen: anticoagulants; hormone sensitive conditions caution; surgery window.

Rhodiola related compounds are best framed through extract level stress fatigue evidence, not isolated compound certainty.

Compound profile with evidence, safety, and practical fit.

No consistent benefit in cancer prevention; essential for deficiency.

Compound profile with evidence, safety, and practical fit.

Taurine may support calmness, exercise fatigue, and cardiovascular contexts without being a direct sedative.

Taurine has insufficient direct human sleep evidence despite plausible inhibitory neurotransmission mechanisms.

Taurine blend entries should be treated as formulation/context rows, not separate proof beyond taurine evidence.

Non protein amino acid from tea associated with calming and attention related effects.

Compound profile with evidence, safety, and practical fit.

Trans resveratrol is the bioactive trans isomer of resveratrol studied for metabolic and vascular biomarkers. Human results are mixed and dose dependent.

Methyl donor that reliably lowers homocysteine biochemically, with uncertain clinical outcome benefit.

Curcumin plus piperine improves curcumin bioavailability and has moderate evidence for inflammation and osteoarthritis pain outcomes.

Compound profile with evidence, safety, and practical fit.

Vitamin D3 + K2 combines vitamin D repletion with vitamin K dependent calcium protein activation; sleep evidence is deficiency dependent and mixed.

Decision ready summary: Zinc is best framed for zinc deficiency; immune support; wound healing support; safety screen: copper deficiency risk with high dose chronic use; nausea.

Biotin is an essential vitamin that corrects deficiency but lacks strong evidence for hair, skin, or nail benefits in non deficient people. High doses can interfere with important lab tests.

Compound profile with evidence, safety, and practical fit.

Creatine plus beta alanine is a performance oriented combination: creatine supports repeated high intensity ATP regeneration, while beta alanine raises muscle carnosine for buffering during hard efforts.

Pentose sugar involved in ATP synthesis with limited evidence in fatigue/cardiac populations.

Compound profile with evidence, safety, and practical fit.

Decision ready summary: Green Tea Extract is best framed for modest fat oxidation; antioxidant support; caffeine assisted metabolic context; safety screen: liver disease; high dose EGCG fasting; stimulant sensitivity.

Nettle root has limited to moderate evidence for modest improvement in BPH urinary symptoms.

Decision ready summary: Plant Sterols is best framed for LDL cholesterol reduction; heart health food/supplement strategy; safety screen: sitosterolemia; fat soluble nutrient monitoring context.

Lactobacillus probiotics have moderate, strain specific evidence for antibiotic associated diarrhea prevention and modest IBS symptom improvement.

Pygeum has moderate evidence for modest improvement in BPH urinary symptoms and urinary flow.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Standardized valerian extract has mixed evidence for sleep quality and should remain limited/inconsistent.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Zinc picolinate is an absorbable zinc form; sleep evidence is indirect and deficiency dependent.

Compound profile with evidence, safety, and practical fit.

Decision ready summary: Saccharomyces boulardii is best framed for antibiotic associated diarrhea risk; traveler’s diarrhea context; gut resilience; safety screen: central venous catheter; severe immunocompromise; critical illness.

May improve IBS symptoms; inconsistent findings.

Decision ready summary: Alpha GPC is best framed for cognitive performance; memory support; power output support; safety screen: low blood pressure; cholinergic sensitivity; anticholinergic medication conflicts.

American Ginseng Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Mitochondrial Health; Metabolic Health; Energy Metabolism. Current workbook signals support mechanistic context around Metabolic Regulation; Glucose Metabolism Support, not treatment claims.

Decision ready summary: Andrographolide is best framed for upper respiratory symptom support; immune response modulation; safety screen: pregnancy; autoimmune disease caution; anticoagulants.

Decision ready summary: Arabinoxylan is best framed for prebiotic fiber support; glycemic response; gut microbiome; safety screen: IBS/FODMAP sensitivity; severe bloating.

Decision ready summary: Artichoke Extract is best framed for indigestion support; cholesterol context; bile flow support; safety screen: bile duct obstruction; gallstones; ragweed allergy.

Decision ready summary: Ashwagandha KSM 66 extract is best framed for stress reduction; perceived anxiety; sleep quality; safety screen: pregnancy; thyroid disorders; autoimmune disease; liver injury history.

Reduces stress, cortisol levels, and anxiety scores.

Decision ready summary: Astaxanthin is best framed for skin photoaging support; oxidative stress; exercise recovery context; safety screen: pregnancy; hormone sensitive medication review.

Decision ready summary: Beetroot extract is best framed for blood pressure support; endurance performance; nitric oxide support; safety screen: hypotension; nitrate medications; kidney stone susceptibility.

Decision ready summary: Beetroot nitrate is best framed for endurance performance; blood pressure support; nitric oxide support; safety screen: hypotension; PDE 5 inhibitors/nitrate medication caution; kidney stone susceptibility.

Decision ready summary: Berberine is best framed for fasting glucose support; insulin resistance context; triglyceride/LDL support; safety screen: pregnancy; breastfeeding; diabetes medications; CYP/P gp medication review.

Decision ready summary: Beta Alanine is best framed for high intensity endurance; repeated sprint performance; muscular buffering; safety screen: paresthesia sensitivity.

Decision ready summary: Beta glucans is best framed for LDL cholesterol reduction; immune support; glycemic response; safety screen: immunosuppressants caution; GI bloating.

Decision ready summary: Bifidobacterium Probiotic is best framed for IBS symptom support; stool regularity; microbiome support; safety screen: severely immunocompromised; central line; critical illness.

Capsaicin is a capsaicinoid associated with chili peppers. Evidence level: moderate.

Decision ready summary: Chamomile is best framed for sleep relaxation; mild anxiety; digestive discomfort; safety screen: ragweed family allergy; sedatives; pregnancy caution.

Essential for liver function, brain development, and neurotransmission.

Decision ready summary: Citicoline / CDP choline is best framed for attention support; cognitive recovery; memory support; safety screen: cholinergic sensitivity; anticholinergic medication conflict.

Decision ready summary: Citrulline Malate is best framed for exercise pump; high rep performance; blood flow support; safety screen: hypotension; nitrate/PDE5 medication review.

Decision ready summary: Coenzyme Q10 is best framed for statin associated muscle symptoms; heart failure support; mitochondrial fatigue; safety screen: warfarin or anticoagulant management; planned surgery.

Decision ready summary: Coenzyme Q10 is best framed for statin associated muscle symptoms; heart failure support; mitochondrial fatigue; safety screen: warfarin or anticoagulant management; planned surgery.

Decision ready summary: Creatine is best framed for strength and power output; lean mass support; cognitive fatigue resistance; safety screen: advanced kidney disease; active renal monitoring concerns.

Creatine monohydrate has strong evidence, but creatine HCl should not inherit formulation specific authority without direct comparative human evidence.

Decision ready summary: Creatine monohydrate is best framed for strength and power output; lean mass support; cognitive fatigue resistance; safety screen: advanced kidney disease; active renal monitoring concerns.

Decision ready summary: Curcumin is best framed for osteoarthritis discomfort; inflammatory pain; exercise soreness; safety screen: anticoagulants; gallbladder disease; planned surgery.

Decision ready summary: Curcumin phytosome is best framed for osteoarthritis pain; inflammation markers; bioavailable curcumin use; safety screen: anticoagulants; gallbladder disease; surgery window.

Decision ready summary: Ginger is best framed for nausea; pregnancy nausea with clinician guidance; digestive comfort; safety screen: bleeding disorder; anticoagulants; gallstones caution.

Modest improvement in cognitive function in dementia.

Decision ready summary: Glucomannan is best framed for satiety; LDL cholesterol support; constipation support; safety screen: swallowing difficulty; bowel obstruction; medication timing conflicts.

Glycinate Magnesium Complex is best framed as a conservative research profile with mechanistic evidence and a focus on Sleep; Cognition; Stress Response; Neurobiology. Current workbook signals support mechanistic context around Neurotransmitter Modulation; Stress Response Modulation, not treatment claims.

Decision ready summary: L Carnitine is best framed for fatigue context; sperm motility research context; recovery support; safety screen: seizure disorder; warfarin; trimethylamine odor sensitivity.

Improves endothelial function and may enhance exercise performance.

Decision ready summary: L Tyrosine is best framed for acute stress performance; sleep deprivation focus; cold/stress resilience; safety screen: MAOIs; hyperthyroidism; levodopa/thyroid medication review.

Lavender Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Sleep; Stress Response; Neurobiology. Current workbook signals support mechanistic context around Neurotransmitter Modulation; Stress Response Modulation, not treatment claims.

Lemon balm may support gentle calm, stress related sleep, and relaxed focus with preparation dependent effects.

Lemon Balm Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Sleep; Cognition; Stress Response; Neurobiology. Current workbook signals support mechanistic context around Neurotransmitter Modulation; Stress Response Modulation, not treatment claims.

Decision ready summary: Lion's Mane is best framed for mild cognitive support; mood context; nerve health research context; safety screen: mushroom allergy; anticoagulant medication review.

Magnesium glycinate may fit sleep quality or muscle tension goals when magnesium intake is low or tolerability matters.

Magnesium oxide has lower bioavailability compared to other forms.

MCT Oil is best framed as a conservative research profile with mechanistic evidence and a focus on Mitochondrial Health; Metabolic Health; Energy Metabolism. Current workbook signals support mechanistic context around Metabolic Regulation; Lipid Metabolism Support, not treatment claims.

Decision ready summary: Milk Thistle is best framed for liver enzyme support context; antioxidant liver support framing; supplement hepatoprotection context; safety screen: ragweed allergy; estrogen sensitive conditions; CYP medication review.

Decision ready summary: NAC is best framed for respiratory mucus support; glutathione replenishment; compulsive behavior research context; safety screen: nitroglycerin; active ulcer; asthma caution.

Decision ready summary: Panax Ginseng is best framed for fatigue reduction; cognitive performance context; energy support; safety screen: warfarin; hypertension; insomnia; stimulant sensitivity.

Panax Ginseng Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Cognition; Mitochondrial Health; Metabolic Health; Energy Metabolism. Current workbook signals support mechanistic context around Metabolic Regulation; Neurotransmitter Modulation; Vascular Function Support; Glucose Metabolism Support; Endothelial Function Support, not treatment claims.

Decision ready summary: Passionflower is best framed for mild anxiety; pre sleep relaxation; nervous tension; safety screen: sedatives; alcohol; pregnancy.

Passionflower Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Sleep; Stress Response; Neurobiology. Current workbook signals support mechanistic context around Neurotransmitter Modulation; Stress Response Modulation, not treatment claims.

Decision ready summary: Peppermint Oil is best framed for IBS abdominal pain; gut spasm; bloating discomfort; safety screen: GERD; hiatal hernia; gallbladder disease; young children.

Decision ready summary: Phosphatidylserine is best framed for age related memory support; stress response; exercise cortisol context; safety screen: anticoagulants caution; soy allergy if soy derived.

Pomegranate Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Cognition; Stress Response; Cardiovascular Health. Current workbook signals support mechanistic context around Oxidative Stress Modulation; Vascular Function Support; Stress Response Modulation; Endothelial Function Support, not treatment claims.

Decision ready summary: Potassium electrolytes is best framed for electrolyte replacement; blood pressure support; muscle function; safety screen: kidney disease; ACE inhibitors/ARBs; potassium sparing diuretics.

Decision ready summary: Psyllium husk is best framed for LDL cholesterol reduction; constipation; glycemic response smoothing; safety screen: bowel obstruction; swallowing difficulty; medication timing conflicts.

Improves endothelial function and reduces blood pressure.

Decision ready summary: SAM e is best framed for depressive symptoms support; osteoarthritis discomfort; methylation context; safety screen: bipolar disorder; MAOIs; serotonergic medications.

Shilajit Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Mitochondrial Health; Hormonal Health; Energy Metabolism. Current workbook signals support mechanistic context around Mitochondrial Support; Hormonal Signaling Context, not treatment claims.

Decision ready summary: Silymarin is best framed for liver enzyme support context; antioxidant liver support; toxin exposure research context; safety screen: ragweed allergy; estrogen sensitive conditions; medication review.

May support detoxification enzymes and reduce oxidative stress.

Decision ready summary: Turmeric is best framed for joint comfort; inflammatory marker support; digestive spice context; safety screen: gallbladder disease; anticoagulants; surgery window.

Decision ready summary: Ubiquinol CoQ10 is best framed for statin associated muscle symptoms; heart failure support; mitochondrial fatigue; safety screen: warfarin or anticoagulant management; planned surgery.

Does not prevent colds in general population but may reduce duration.

Decision ready summary: Vitamin D is best framed for vitamin D deficiency correction; bone health; immune support when deficient; safety screen: hypercalcemia; sarcoidosis; high dose use without labs.

Decision ready summary: Vitamin D3 is best framed for vitamin D deficiency correction; bone health; immune support when deficient; safety screen: hypercalcemia; sarcoidosis; high dose use without labs.

May improve bone mineral density and reduce vascular calcification.

5 HTP may support sleep onset or mood context through serotonin precursor pathways, but use is highly interaction dependent.

Organosulfur garlic derivative formed from allicin breakdown and linked to antiplatelet and inflammatory signaling effects.

Phenylpropene from fennel and anise associated with digestive and anti inflammatory actions.

Human evidence is insufficient for metabolic, cardiovascular, or longevity claims.

Flavonoid glycoside associated with inflammatory pathway control.

Astragalus saponin linked to metabolic signaling and tissue protective pathways.

Baicalein is the aglycone partner of baicalin and is widely studied in inflammation, redox biology, and cancer mechanism literature. The evidence remains mainly preclinical, with limited isolated human intervention data.

Baicalin is a flavone glycoside associated with Scutellaria species and related TCM research. Its strongest support is preclinical, especially for inflammatory and oxidative stress pathways, while direct isolated compound human evidence remains limited.

Compound profile with evidence, safety, and practical fit.

Decision ready summary: Beta sitosterol is best framed for BPH urinary symptoms; cholesterol support; safety screen: sitosterolemia; fat soluble vitamin absorption concerns.

Biflavone from Ginkgo and related taxa associated with inflammatory pathway modulation.

Biochanin A is an isoflavone present in red clover and other legumes, with interest centered on estrogen related, metabolic, and anti inflammatory signaling. Human evidence for the isolated compound remains limited compared with broader isoflavone mixtures.

Compound profile with evidence, safety, and practical fit.

Decision ready summary: Boswellia AKBA standardized is best framed for osteoarthritis pain; joint function; inflammatory discomfort; safety screen: pregnancy caution; anticoagulants; GI irritation.

Decision ready summary: Bromelain is best framed for sinus inflammation context; post exercise soreness context; protein digestion support; safety screen: pineapple allergy; anticoagulants; planned surgery.

Burdock root has preclinical antioxidant and anti inflammatory signals but little reliable human clinical evidence.

Phthalide constituent associated with PI3K/Akt and inflammatory pathway modulation.

Coffee diterpene best known from coffee lipids and studied for xenobiotic response and inflammatory signaling effects.

Phenolic acid broadly present in herbs and coffee, commonly linked to NF κB and MAPK signaling.

Calycosin is an isoflavone associated especially with Astragalus derived phytochemistry. The literature emphasizes vascular, estrogen related, and antioxidant signaling in preclinical models more than replicated human trials.

Carnosic acid is a diterpene phenol best known from rosemary and sage. It is mainly supported by antioxidant, neuroprotective, and anti inflammatory preclinical literature rather than robust human trials.

Phenolic diterpene from rosemary with antioxidant and anti inflammatory pathway activity.

Carvacrol is a monoterpenoid phenol concentrated in oregano and thyme chemotypes. It is best supported by preclinical antimicrobial and anti inflammatory data, with human evidence for isolated use still sparse.

Catalpol is an iridoid glycoside linked to metabolic and cytoprotective signaling.

Catechin is a flavanol found in tea, cacao, and many botanicals, but much of the human literature evaluates catechin rich mixtures rather than isolated catechin alone. That makes the mechanism signal stronger than the isolated clinical signal.

Quinone methide triterpenoid linked to HSP90 inhibition and NF κB suppression.

Caffeic acid derivative prominent in echinacea and chicory with anti inflammatory signaling activity.

Caffeoylquinic acid widely reported from coffee and artichoke with AMPK and glucose metabolism pathway effects.

Decision ready summary: Chondroitin is best framed for knee osteoarthritis comfort; cartilage support context; safety screen: warfarin; bleeding disorder; planned surgery.

Decision ready summary: Cinnamon extract is best framed for blood glucose support; insulin sensitivity support; safety screen: liver disease; anticoagulant medication caution; pregnancy high dose caution.

Decision ready summary: Collagen Peptides is best framed for skin elasticity; joint comfort; connective tissue support; safety screen: allergy to source material.

Guggul triterpenoid linked to lipid signaling and inflammatory control.

Decision ready summary: Cranberry is best framed for recurrent UTI prevention context; urinary tract adhesion support; safety screen: warfarin caution; kidney stone history.

Saffron carotenoid aglycone linked to PI3K/Akt and Nrf2 pathway activity.

Saffron carotenoid glycoside reported to influence PI3K/Akt and MAPK signaling.

Abietane diterpene from Salvia miltiorrhiza with anticancer properties.

Decision ready summary: Curcumin + piperine is best framed for osteoarthritis pain; inflammation markers; bioavailability enhanced curcumin use; safety screen: drug interaction sensitive medications; anticoagulants; gallbladder disease.

Curcuma sesquiterpenoid linked to survival and apoptotic pathways.

Isoflavone found in soy and clover, frequently linked to estrogen receptor and MAPK pathway activity.

Isoflavone glycoside associated with hormone related and glycemic effects.

Coumarin derivative reported with JAK/STAT and NF κB inhibitory activity.

Phytoestrogen precursor compound associated with Pueraria mirifica and estrogenic signaling.

Devils Claw Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Inflammation. Current workbook signals support mechanistic context around Inflammatory Signaling Modulation, not treatment claims.

Dietary nitrates have moderate evidence for blood pressure reduction and improved exercise efficiency.

Major kavalactone from kava linked to calming CNS activity through GABAergic mechanisms.

Steroidal sapogenin broadly associated with endocrine and metabolic signaling.

Human RCT evidence supports diosmin for improving symptoms of chronic venous insufficiency and hemorrhoidal disease.

Electrolyte solutions improve hydration and performance during prolonged exercise.

Evidence for fatigue or stress adaptation is insufficient for authority status without verified RCT support.

Phenylpropanoid glycoside from Eleuthero associated with adaptogenic effects.

Lignan glycoside from Eleuthero linked to endurance and stress adaptation.

Polyphenolic acid associated with pomegranate and berry sources, linked to Nrf2 and NF κB signaling.

Benzoquinone compound linked to apoptotic and inflammatory signaling.

Flavan 3 ol associated with cacao and tea, commonly linked to PI3K/Akt and endothelial nitric oxide signaling.

Tea catechin involved in redox regulation and cell signaling.

Hydroxycoumarin reported from chicory and Artemisia with lipoxygenase and NF κB pathway effects.

Decision ready summary: Extended release melatonin is best framed for sleep maintenance; circadian rhythm support; safety screen: pregnancy without clinician guidance; sedatives; next day drowsiness risk.

Sesquiterpene alcohol linked to lipid signaling and pathway modulation.

Phenolic acid common in grains and Angelica related herbs, linked to Nrf2 and PI3K/Akt signaling.

Isoflavone commonly reported from clover and astragalus with estrogen receptor and PI3K/Akt pathway effects.

Methoxylated coumarin linked to Nrf2 activation and inflammatory pathway suppression.

Limited evidence for stress reduction.

Flavonol from Alpinia officinarum with antimicrobial and anti inflammatory roles.

Gallic acid is a small phenolic acid present across many herbs, teas, and fruits. It is well represented in antioxidant and inflammatory pathway studies, but isolated human outcome evidence is limited.

Catechin derivative present in tea with antioxidant signaling activity.

Isoflavone strongly associated with soy and clover, commonly linked to estrogen receptor and PI3K/Akt signaling.

Major ginsenoside with neuroprotective and metabolic signaling effects.

Major ginsenoside associated with neurovascular and survival signaling.

Glucosinolate from moringa that yields bioactive isothiocyanates after hydrolysis.

Decision ready summary: Glucosamine is best framed for knee osteoarthritis symptom support; long term joint comfort; safety screen: shellfish allergy; warfarin; diabetes medication review.

Triterpene saponin from licorice with HMGB1 and NF κB pathway activity.

Glycyrrhizin is the major triterpenoid saponin from licorice with anti inflammatory and regional hepatology use. Its safety profile is limited by pseudoaldosteronism risk.

Goldenseal contains berberine and hydrastine, but strong human efficacy evidence is lacking and interaction risk is meaningful.

Gotu kola has moderate human support for chronic venous insufficiency symptoms, with additional cognitive claims remaining limited.

Peptide constituent associated with sweet signal blocking and glycemic effects.

Harpagoside is a devil's claw iridoid associated with pain and inflammatory pathway modulation.

Human RCT evidence suggests hesperidin may improve endothelial function and modestly affect blood pressure, though findings are population specific.

Olive phenolic metabolite linked to Nrf2 activation and PI3K/Akt signaling.

Iberogast is best framed as a conservative research profile with mechanistic evidence and a focus on Digestive Health. Current workbook signals support mechanistic context around limited source backed mechanism signals, not treatment claims.

Compound profile with evidence, safety, and practical fit.

Furanocoumarin associated with cholinesterase inhibition and calcium channel related signaling effects.

Related furanocoumarin commonly reported from Angelica/Cnidium with cholinesterase and MAPK pathway activity.

Protoberberine alkaloid associated with glucose and inflammatory signaling regulation.

Coffee diterpene often paired with cafestol and associated with redox and inflammatory pathway modulation.

Major kavalactone with calming and channel modulating pharmacology.

Collective kavalactone fraction associated with anxiolytic and ion channel activity.

Decision ready summary: Lactobacillus Probiotic is best framed for antibiotic associated diarrhea context; IBS symptom support; gut microbiome support; safety screen: severely immunocompromised; central line; critical illness.

Naphthoquinone pigment linked to inflammatory signaling control.

Compound profile with evidence, safety, and practical fit.

Phthalide constituent of Angelica/Ligusticum associated with calcium channel related and NF κB effects.

Lithium orotate provides lithium ions, but robust human evidence for this salt form is lacking. Safety concerns should be framed from lithium's narrow therapeutic window and kidney/thyroid risk.

Loganin is an iridoid glycoside tied to antioxidant response and survival pathways.

Decision ready summary: Lutein is best framed for macular pigment support; age related eye health; screen heavy lifestyle support; safety screen: none significant; review pregnancy supplement stack.

Flavone associated with thyme and artichoke, commonly linked to NF κB and MAPK signaling.

May improve sexual desire; limited evidence.

Maca Root Extract is best framed as a conservative research profile with mechanistic evidence and a focus on Hormonal Health. Current workbook signals support mechanistic context around Hormonal Signaling Context, not treatment claims.

Xanthone glucoside linked to metabolic and redox responsive signaling.

Xanthone related metabolite linked to metabolic and redox responsive pathways.

Metformin shows superior and consistent glycemic control vs most natural compounds.

Flavonol associated with inflammatory and cell survival pathway modulation.

Morroniside is a Cornus iridoid with cytoprotective pathway activity.

Polyhydroxylated flavonol reported from tea and berry sources with MAPK and NF κB pathway activity.

NAD+ is a central redox cofactor involved in mitochondrial energy metabolism and cellular signaling.

Reduced nicotinamide adenine dinucleotide with limited evidence in fatigue syndromes.

Citrus flavanone reported to influence AMPK and PI3K/Akt signaling.

Citrus glycoside that converts toward naringenin related metabolic and inflammatory pathway activity.

Andrographis diterpene glycoside associated with inflammatory and survival signaling modulation.

Sesquiterpene alcohol associated with calming and cytoprotective signaling.

NMN is an NAD+ precursor studied for metabolic and aging related biomarkers. Human evidence is emerging, with limited clinical outcome data and uncertain long term safety.

Nicotinic acid is a vitamin B3 form with strong lipid effects but limited cardiovascular outcome benefit when added to statins. Safety concerns include flushing, hepatotoxicity, hyperglycemia, and gout.

Oleacein is an olive secoiridoid linked to antioxidant response and inflammatory pathway control.

Oleocanthal is an olive phenolic aldehyde associated with COX related anti inflammatory signaling.

Isoflavone glycoside tied to receptor level estrogenic signaling.

Compound profile with evidence, safety, and practical fit.

Prenylated coumarin reported from Cnidium and related Apiaceae with PDE4 linked and PI3K/Akt signaling activity.

Phenolic ketone associated with inflammatory and antioxidant response signaling.

Naphthoquinone associated with inflammatory and redox signaling effects.

Furocoumarin associated with phytoestrogen like and MAPK linked signaling effects.

Compound profile with evidence, safety, and practical fit.

Rosmarinic acid is a caffeic acid ester abundant in rosemary, lemon balm, perilla, and other Lamiaceae herbs. It is most convincing as an anti inflammatory and mast cell modulating compound, but isolated compound human evidence remains thin.

Flavonol glycoside commonly reported from buckwheat and St.

Rhodiola marker glycoside associated with metabolic and cytoprotective pathway activity.

Lignan from Schisandra associated with Nrf2 activation and PI3K/Akt signaling.

Coumarin constituent associated with NF κB suppression and calcium channel related activity.

Phthalide derivative commonly reported from chuanxiong and Angelica with MAPK and ion channel linked activity.

Naphthoquinone pigment associated with metabolic and inflammatory pathway effects.

Major flavonolignan of milk thistle with STAT3 and PI3K/Akt pathway activity.

Minor flavonolignan from milk thistle associated with liver protective effects.

Decision ready summary: Sodium electrolytes is best framed for sweat replacement; endurance hydration; rehydration; safety screen: hypertension; heart failure; kidney disease; sodium restriction.

Phytosterol linked to receptor level lipid signaling and pathway modulation.

Oxidative black tea polyphenol associated with NF κB and MAPK pathway effects.

Complex black tea polyphenol fraction broadly associated with inflammatory and redox pathway modulation.

Quinone constituent of Nigella sativa with reported NF κB suppression and Nrf2 signaling support.

Alkaloid found in coffee and fenugreek linked to metabolic and neuroprotective effects.

L tryptophan has moderate evidence for modest sleep latency reduction.

Simple phenolic alcohol linked to antioxidant response and survival signaling.

Simple coumarin distributed across Apiaceae with antioxidant response and MAPK pathway activity.

Valerian iridoid ester fraction associated with sedative and stress signaling effects.

Also known as acteoside; linked to inflammatory signaling control.

Essential for vision and immune function; excess causes toxicity.

Vitamin B3 is the umbrella nutrient category for niacin forms including nicotinic acid and niacinamide.

Reactive withanolide from ashwagandha with strong inflammatory and stress pathway effects.

Wogonin is a flavone associated with Scutellaria research and immune neuroinflammatory pathway studies. The compound is biologically interesting, but isolated human efficacy evidence remains thin.

Linear furocoumarin reported from Angelica and parsnip with MAPK and phosphodiesterase related activity.

Decision ready summary: Zeaxanthin is best framed for macular pigment support; retinal antioxidant protection; eye health stacks; safety screen: none significant; review pregnancy supplement stack.

Improves gastric mucosal healing and reduces ulcer symptoms.

Keto boswellic acid associated with 5 LOX related signaling and inflammatory modulation.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Acetyl 11 keto beta boswellic acid is a boswellic acid emphasized in Boswellia standardization discussions. Its relevance is mechanistically strong for inflammatory pathways, but isolated compound human evidence is much thinner than extract level evidence.

Acetylated boswellic acid linked to leukotriene pathway suppression in Boswellia.

Shikonin derivative linked to inflammatory and apoptotic signaling.

Phenylethanoid glycoside with inflammatory pathway modulation.

Alkylamides is a fatty acid amides associated with echinacea purpurea. Evidence level: mixed.

Allicin is a organosulfur compound associated with garlic. Evidence level: mixed.

Phenylpropanoid ether from Acorus species studied for CNS active and cholinergic effects.

Major mangosteen xanthone with inflammatory and apoptotic signaling activity.

Minor tobacco alkaloid associated with nicotinic signaling and inflammatory pathway effects.

Angelicin is a furocoumarin associated with photosensitizing pharmacology and occasional discussion in skin and bone research. The evidence base is primarily mechanistic, with efficacy claims constrained by limited human data and safety context.

Triterpenoid from Terminalia arjuna associated with cardioprotective effects.

Ashitaba has preclinical chalcone research but insufficient human clinical evidence.

Triterpenoid aglycone associated with tissue repair and inflammatory pathway effects.

C glucosyl dihydrochalcone characteristic of rooibos with metabolic and redox signaling activity.

Sesquiterpene lactone associated with immune and survival signaling.

Atractylodes lactone linked to inflammatory signaling control.

Sesquiterpene lactone associated with immune and cytoprotective pathways.

Aucubin is an iridoid glycoside associated with inflammatory pathway suppression.

Compound profile with evidence, safety, and practical fit.

Human evidence for BCAA benefits is inconsistent and often inferior to complete protein or EAA contexts; authority status is insufficient for broad claims.

BCAAs may reduce muscle soreness but limited effect on performance.

Bis benzylisoquinoline alkaloid from barberry type plants with anti inflammatory and signaling modulatory activity.

Methoxypsoralen constituent of citrus and Psoralea commonly linked to MAPK and inflammatory pathway modulation.

Sesquiterpene linked to cannabinoid receptor and inflammatory signaling.

Betaine nitrate combines betaine and nitrate mechanisms, but direct human evidence for the combined compound is insufficient.

Pentacyclic triterpenoid found across several botanicals and fungi, often studied for inflammatory and apoptotic signaling effects.

Improves high intensity exercise performance.

Sesquiterpene alcohol associated with inflammatory pathway control.

Pentacyclic triterpenoid boswellic acid from frankincense resin with 5 LOX and inflammatory pathway activity.

Compound profile with evidence, safety, and practical fit.

Supports bone mineral density; modest fracture prevention.

Compound profile with evidence, safety, and practical fit.

Oxidized caryophyllene derivative associated with inflammatory and apoptotic signaling.

Cat's claw has limited human evidence for arthritis symptom improvement and mostly preclinical immune modulating data.

Bisbenzylisoquinoline alkaloid associated with NF κB suppression and PI3K/Akt pathway effects.

Chaga has primarily preclinical antioxidant research and notable renal safety concerns from oxalate exposure case reports.

Aromatic azulene derivative linked to inflammatory mediator modulation.

Bitter melon sterol glycoside mixture associated with glucose uptake and metabolic regulation.

Compound profile with evidence, safety, and practical fit.

Major aromatic aldehyde in cinnamon bark influencing metabolic and inflammatory signaling.

Monoterpene aldehyde common in citronella type oils, recognized for aromatic and sensory channel activity.

Compound profile with evidence, safety, and practical fit.

Coenzyme A is a central metabolic cofactor, but oral supplementation has no established human benefit. Evidence is biochemical only.

Berberine family alkaloid linked to metabolic regulation pathways.

Diterpenoid from Tinospora cordifolia linked to anti inflammatory activity.

Protoberberine alkaloid from Coptis with metabolic and inflammatory pathway activity.

Compound profile with evidence, safety, and practical fit.

Compound profile with evidence, safety, and practical fit.

Triterpenoid associated with glucose disposal and metabolic signaling.

Compound profile with evidence, safety, and practical fit.

Dandelion root is traditionally used for digestive and diuretic support, but human clinical evidence is minimal.

Sesquiterpene lactone linked to inflammatory and apoptotic signaling.

Minor kavalactone from kava associated with monoamine and GABAergic signaling effects.

Kavalactone from kava associated with GABAergic activity and monoamine related signaling.

Compound profile with evidence, safety, and practical fit.

Phenylpropene associated with monoamine related and sensory signaling.

Sesquiterpene lactone associated with inflammatory signaling control.

Anthraquinone reported from rhubarb with NF κB and MAPK pathway activity.

Gallated catechin from tea with anti inflammatory signaling effects.

Eugenol is a phenylpropanoid most associated with clove and other aromatic herbs. It is best supported by preclinical work showing analgesic, anti inflammatory, antimicrobial, and membrane active effects rather than broad human outcome evidence.

Compound profile with evidence, safety, and practical fit.

Fisetin is a flavonoid studied for senolytic and neuroprotective effects, mainly in preclinical models. Human clinical evidence remains minimal.

Diterpene from Coleus known for direct adenylyl cyclase activation.

Galantamine is best framed as a conservative research profile with mechanistic evidence and a focus on Cognition. Current workbook signals support mechanistic context around Neurotransmitter Modulation, not treatment claims.

Compound profile with evidence, safety, and practical fit.

Polyisoprenylated benzophenone linked to inflammatory and epigenetic signaling.

Heat processed ginsenoside linked to inflammatory and angiogenic pathway control.

Glycerol can increase fluid retention in hyperhydration protocols, but performance benefits are mixed.

Triterpenoid metabolite of glycyrrhizin associated with inflammatory signaling modulation.

Graviola is safety concerning due to annonaceous acetogenins and neurotoxicity signals; no clinical efficacy evidence supports therapeutic use.

Compound profile with evidence, safety, and practical fit.

Steroidal ketone associated with bile acid receptor and inflammatory pathway effects.

Triterpenoid aglycone linked to glycemic regulation and intestinal glucose handling.

Triterpenoid saponin complex from gymnema linked to intestinal glucose handling.

HCG should not be promoted for weight loss: FDA warns against HCG weight loss products, and clinical evidence shows weight loss comes from severe calorie restriction rather than HCG.

Biphenolic compound from Magnolia bark with anxiolytic and anti inflammatory activity.

Horsetail is a silica containing botanical with insufficient human clinical evidence and safety concerns with prolonged use.

Minor huperzine alkaloid linked to cholinergic support pathways.

Prevents iodine deficiency disorders and supports thyroid hormone production.

Isoleucine contributes to glucose uptake and muscle metabolism, but isolated effects are less studied.

Kanna has preliminary human evidence for anxiety/mood effects but remains limited by small studies and extract variability.

Ellagitannin linked to glucose transport and metabolic regulation.